OxyFile #269
TI Synthesis of 4-hydroperoxy derivatives of ifosfamide and
trofosfamide by direct ozonation and preliminary antitumor
evaluation in vivo.
AU Hohorst-HJ; Peter-G; Struck-RF
SO Cancer-Res. 1976 Jul; 36(7 PT 1): 2278-81
ISSN 0008-5472
LA ENGLISH
CP UNITED-STATES
PT JOURNAL-ARTICLE
UI 76208091
Abstract
A one-step synthesis of 4-hydroperoxyifosfamide and 4-
hydroperoxytrofosfamide is described. The method involves direct
ozonation of ifosfamide and trofosfamide and offers improved yields
in comparison with Fenton oxidation and greater convenience in
comparison with ozonation of the appropriate 3-butenyl
phosphorodiamidate. Evaluation of the 4-hydroperoxy derivatives of
cyclophosphamide, ifosfamide, and trofosfamide against leukemia L1210
in vivo suggests a superior effect for the ifosfamide derivatie.